Lifestyle and personal factors associated with having macroscopic residual disease after ovarian cancer primary cytoreductive surgery

MT Phung; PM Webb; A DeFazio; S Fereday; AW Lee; DDL Bowtell; PA Fasching; EL Goode; MT Goodman; BY Karlan; J Lester; K Matsuo; F Modugno; JD Brenton; T Van Gorp; PDP Pharoah; JM Schildkraut; K McLean; R Meza; B Mukherjee; J Richardson; B Grout; A Chase; C McKinnon Deurloo; KL Terry; GE Hanley; MC Pike; A Berchuck; SJ Ramus; CL Pearce

Journal article

Lifestyle and personal factors associated with having macroscopic residual disease after ovarian cancer primary cytoreductive surgery

MT Phung, PM Webb, A DeFazio, S Fereday, AW Lee, DDL Bowtell, PA Fasching, EL Goode, MT Goodman, BY Karlan, J Lester, K Matsuo, F Modugno, JD Brenton, T Van Gorp, PDP Pharoah, JM Schildkraut, K McLean, R Meza, B Mukherjee Show all

Gynecologic Oncology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2023

DOI: 10.1016/j.ygyno.2022.10.018

Abstract

Objective: The presence of macroscopic residual disease after primary cytoreductive surgery (PCS) is an important factor influencing survival for patients with high-grade serous ovarian cancer (HGSC). More research is needed to identify factors associated with having macroscopic residual disease. We analyzed 12 lifestyle and personal exposures known to be related to ovarian cancer risk or inflammation to identify those associated with having residual disease after surgery. Methods: This analysis used data on 2054 patients with advanced stage HGSC from the Ovarian Cancer Association Consortium. The exposures were body mass index, breastfeeding, oral contraceptive use, depot-medroxyprogesteron..

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